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#1 2018-06-14 13:25:12

Registered: 2018-06-14
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Deletions of part of the short arm of chromosome 17 (del 17p), which target the cell cycle regulating protein p53 are particularly deleterious. The deletion of p53 leads to deregulation of numerous genes including microRNAs (miR 34a).[28] Patients with this abnormality have significantly short interval before they require therapy and a shorter survival. This abnormality is found in 5 10% of patients with CLL..

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